Sorafenib Metabolism Is Significantly Altered in the Liver Tumor Tissue of Hepatocellular Carcinoma Patient
Figure 3
Sorafenib metabolism by UGT1A9 (A) and UGT1A9 protein expression (B) in pooled NHLMs, THLMs and CHLMs.
The formation rate of M7 expressed as peak area ratio (mean ± SD). All the experiments were carried out in triplicate. One-way ANOVA, with or without Tukey–Kramer multiple comparison (post-hoc) tests, was used for data analysis. “*” denotes statistical significance (P<0.05); “**” denotes statistical significance (P<0.01), “***” denotes statistical significance (P<0.001).