Fenofibrate Improves Renal Lipotoxicity through Activation of AMPK-PGC-1α in db/db Mice
Figure 4
Pro-apoptotic BAX, anti-apoptotic BCL-2, and TUNEL assay in the renal cortex of db/m and db/db mice with or without fenofibrate treatment.
Protein lysates (40 µg) from renal cortex were separated by SDS-PAGE and analyzed by Western blotting. A) Representative Western blot analysis of the BAX, BCL-2, and β-actin levels. B) The quantitative analyses of the results of the BCL-2/BAX ratio are shown. C) Representative immunohistochemical staining for TUNEL-positive cells and the quantitative analyses of the results are shown. **p<0.01 vs. db/m control, db/m Feno, and db/db Feno mice.