Fenofibrate Improves Renal Lipotoxicity through Activation of AMPK-PGC-1α in db/db Mice
Figure 1
Changes in glomerular phenotypes in fenofibrate-treated db/db mice.
Glomerular mesangial fractional area, TGF-β1 and collagen IV (Col IV) expression, and a F4/80-positive cell infiltration in the glomerulus in the cortical area of the db/m and db/db mice, with or without fenofibrate treatment. A) Representative sections stained with periodic acid-Schiff reagent and representative immunohistochemical staining for TGF-β1, type IV collagen, and F4/80-positive cells (dark brown) are shown (original magnification 400x). B-E) Quantitative analyses of the results for the mesangial fractional area (%), TGF-β1, type IV collagen, and F4/80-positive cells (fold) are shown. Abbreviations: Col IV, type IV collagen; PAS, periodic acid-Schiff stain, **p<0.01 vs. the db/m Cont (db/m), db/m Feno (db/m+Feno), and db/db Feno (db/db+Feno) mice.