B-Ring-Aryl Substituted Luotonin A Analogues with a New Binding Mode to the Topoisomerase 1-DNA Complex Show Enhanced Cytotoxic Activity
Figure 9
Results of the cytotoxicity assays.
The cytotoxicities of compounds 3a–g are expressed as percentage of cell growth relative to the negative control. Error bars account for the standard error. Asterisks indicate statistically significant differences between a drug and the model compound 3a. Camptothecin was employed as a positive control (0% growth) at 25 and 2.5 µM concentrations.