B-Ring-Aryl Substituted Luotonin A Analogues with a New Binding Mode to the Topoisomerase 1-DNA Complex Show Enhanced Cytotoxic Activity
Figure 4
Isolation of open luotonin analogues that behave as intermediates of the Friedländer reaction.
By interrupting the reaction at mid-course, it was possible to isolate enamines 4 and prove their role as intermediates of the Friedländer reaction by verifying that they afforded the final products under our standard conditions.