B-Ring-Aryl Substituted Luotonin A Analogues with a New Binding Mode to the Topoisomerase 1-DNA Complex Show Enhanced Cytotoxic Activity
Figure 3
Synthesis of luotonin A and its analogues by CAN-catalyzed Friedländer reactions.
The reaction between the o-aminocarbonyl compounds 1 and the dehydrovasicinone 2 was performed in refluxing ethanol, in the presence of Ce(IV) ammonium nitrate (CAN) as a Lewis acid.