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Overrepresentation of Glutamate Signaling in Alzheimer's Disease: Network-Based Pathway Enrichment Using Meta-Analysis of Genome-Wide Association Studies

Figure 5

Overrepresented glutamate signaling components in the functional synapse.

The original version of the hsa04724 KEGG pathway (Glutamatergic synapse) is shown. Black arrows denote direct molecular interaction or relation between gene products (green squares) or other types of molecules (unfilled circles), while black arrows with dashed lines denote an indirect effect between the each node. The relationship with other KEGG pathways is shown with the presence of white round rectangles. Gene symbols in components belonging to Meta-GW and META-GATES SN1 are denoted in red.

Figure 5

doi: https://doi.org/10.1371/journal.pone.0095413.g005