Calorie Restriction Decreases Murine and Human Pancreatic Tumor Cell Growth, Nuclear Factor-κB Activation, and Inflammation-Related Gene Expression in an Insulin-like Growth Factor-1−Dependent Manner
Figure 5
Diet effects on MiaPaCa-2 tumor burden and gene expression.
A, Mean body weight of athymic nude mice per group after 16 weeks of diet treatment (prior to tumor injection). B, MiaPaCa-2 tumor volume measured over 6 weeks of tumor growth. Line graphs represent mean ± SD. C, MiaPaCa-2 tumor weight measured at study termination; line in scatter plot represents median tumor weight. A, B, & C, n = 14/group. D, Diet effects on mRNA expression of NF-κB downstream targets. Data represent CR, relative to CON, mRNA expression, mean ± SEM (n = 6/group). Significance (p<0.05) is denoted by *. CON, control; CR, calorie restriction.