Insight into the Interactions between Novel Isoquinolin-1,3-Dione Derivatives and Cyclin-Dependent Kinase 4 Combining QSAR and Molecular Docking
Figure 5
Std* coeff contour maps of CoMFA analysis in combination with compound 12.
(a) Steric fields: green contours suggest regions where bulky groups increase activity, while yellow contours indicate regions where bulky groups decrease activity, and (b) Electrostatic fields: blue contours represent regions where electron-donating groups increase activity, while red contours highlight regions where electron-withdrawing groups increase activity.