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Correlative Scanning-Transmission Electron Microscopy Reveals that a Chimeric Flavivirus Is Released as Individual Particles in Secretory Vesicles

Figure 5

TEM analysis of Vero cells selected by the CSEMTEM method.

(A): Electron-dense chimeric viral particles were observed at the cell surface (black arrows). (B, C and D): Several released particles were observed at the site of small-vesicle exocytosis at the plasma membrane (white arrows). Scale bars: 0.2 µm in A, B and C; 0.1 µm in D.

Figure 5

doi: https://doi.org/10.1371/journal.pone.0093573.g005