The CpG Island Encompassing the Promoter and First Exon of Human DNMT3L Gene Is a PcG/TrX Response Element (PRE)
Figure 5
DNMT3L DMC interacts with Polycomb group of proteins.
A. The 15 panels show comparison of eye color phenotype between representative DNMT3L DMC transgenic lines (25.2.12) and their counterpart lines after crossing with the respective Polyomb (Pc1, esc2, AsxXF53, Psc′, PclT1, ScmR5-13B, Phd, Pho), Trithorax (Ash21, Mor1, Bbrm2, TrlR85, Trx1) and Supressor of Variegation (Su(var)2-501, Su(var)3-906) mutants. 3LL/+, heterozygous 3L-L transgenic lines; 3LL/−, their respective counterparts after crosses with the respective mutant (− is the name of the Polycomb, Trithorax or Suvar mutant). B. Comparison of eye color pigmentation between 3L-L transgenic lines (25.2.12 and 25.2.29) and their counterparts from crosses with the various mutant lines. Each bar represents eye color pigmentation for progeny from crosses of individual transgenic lines with a particular mutant, the details of which are provided below the X-axis. As the assays were done in batches, the eye pigmentation for the control 3L-L transgenic line was done for each batch and is shown as white bars (P/+ male with W1118) in the graphs. Error bars represent Standard Deviation (S.D.). Asterisks indicate significant difference (Student's t test, * - p<0.05, ** - p<0.01).