Pancreatic Alpha-Cell Dysfunction Contributes to the Disruption of Glucose Homeostasis and Compensatory Insulin Hypersecretion in Glucocorticoid-Treated Rats
Figure 7
11β Hydroxysteroid dehydrogenase type 1 [11βHSD-1) content and cellular distribution in the pancreas in DEX rats.
A: Representative immunoblots for 11βHSD-1 and β-actin and their quantification (bar graphs) in DEX and CTL islet lysates (n = 6 independent samples). Data are the mean ± SEM. C: Immunostaining of pancreas sections from DEX and CTL rats for glucagon (red) and 11βHSD-1 (green). Merged in orange. n = 3 pancreases. Scale bars = 7.5 µm.