Pancreatic Alpha-Cell Dysfunction Contributes to the Disruption of Glucose Homeostasis and Compensatory Insulin Hypersecretion in Glucocorticoid-Treated Rats
Figure 6
11-Dehydrocorticosterone [11-DHC) stimulates insulin secretion under basal glucose conditions in islets isolated from DEX rats.
A: Insulin secretion in response to incubation with 5.6 mmol/l glucose with or without 11-DHC or carbenoxolone in islets isolated from DEX and CTL rats (n = 10 wells). B: Insulin secretion in response to incubation with 16.7 mmol/l glucose with or without 11-DHC or carbenoxolone in islets isolated from DEX and CTL rats (n = 10 wells). Data are the mean ± SEM. *** p<0.001 vs. CTL. † p<0.05 vs. 5.6 mmol/l glucose. ‡ p<0.05 vs. 5.6 mmol/l glucose plus 100 nmol/l 11-DHC.