Pancreatic Alpha-Cell Dysfunction Contributes to the Disruption of Glucose Homeostasis and Compensatory Insulin Hypersecretion in Glucocorticoid-Treated Rats
Figure 4
The number of docked glucagon granules is increased in the α-cells of DEX rats.
A: Electron micrographs of α-cells from CTL and DEX rats. The images demonstrate an enlargement of the Golgi complex (GC) and the increase in glucagon granules docked to the plasma membrane in the DEX α-cells (*). N, Nucleus; Mi, mitochondria. B: Profile of glucagon granules per median section of α-cells. C: Proportion of granules docked to the plasma membrane of α-cells. Data are the mean ± SEM (n = 16 cells in each condition). ** p<0.01 vs. CTL.