Phenotypic T Cell Exhaustion in a Murine Model of Bacterial Infection in the Setting of Pre-Existing Malignancy
Figure 5
Correlation of coinhibitory receptor expression to antigen-specific cytokine production.
A) The frequency of PD-1, 2B4, and BTLA expression was compared to the frequency of cells producing IFN-γ. Increased inhibitory receptor expression is correlated with reduced cytokine production. n = 8–10 (PD-1 and BTLA) and 4–5 (2B4). B) The frequency of PD-1, 2B4, and BTLA expression was compared to the frequency of cells producing IL-2. Increased inhibitory receptor expression is correlated with increased cytokine production; n = 8–10 (PD-1 and BTLA) and 4–5 (2B4).