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L-Arginine Stimulates Fibroblast Proliferation through the GPRC6A-ERK1/2 and PI3K/Akt Pathway

Figure 2

Effects of l-arginine deprivation and stimulation on apoptosis in fibroblasts.

(A) Apoptosis was measured using the TUNEL assay in l-arginine-deprived and -treated fibroblasts. (B) Quantification of the data from (A). **p<0.01, as compared with the control group (Student’s t test). (C) The number of cell death using the 0.1% trypan blue staining in l-arginine-deprived and -treated fibroblasts. **p<0.01, as compared with the control group (Student’s t test).

Figure 2

doi: https://doi.org/10.1371/journal.pone.0092168.g002