Cyclotide Structure–Activity Relationships: Qualitative and Quantitative Approaches Linking Cytotoxic and Anthelmintic Activity to the Clustering of Physicochemical Forces
Figure 12
Chart of molecular weight and flexibility in cyclotides.
This chart illustrates the correlation between flexibility and molecular weight. Points where multiple cyclotides overlap are indicated by the letters A-E; the cyclotides at these points are: A (M42, M43), B (M5, M9, M12, M14, M17, M24, M25), C (M4, H2), D (M2, M6, M10, M11, M16) and E (B10, B21). The linear cyclotide (L1 and L2) is relatively flexible since it lacks a cyclic backbone. The members of the hybrid cyclotide subfamily (H4, H6) have high molecular weights and flexibility values.