Cyclotide Structure–Activity Relationships: Qualitative and Quantitative Approaches Linking Cytotoxic and Anthelmintic Activity to the Clustering of Physicochemical Forces
Figure 7
Moment plot (LM, EM) for the studied cyclotides.
The cyclotides, labeled according to their subfamily (M for Möbius, B for bracelet, H for hybrid) and with their unique numbers, were plotted on a map based on their lipophilic moments (LM) and HBD amphipathic moments (EM). They cluster into two groups based on their moments: one group has low moments and exhibits low activity while members of the other group have high moments and exhibit moderate or high activity. The synthetic hybrid cyclotides, [W23K, P24N, V25K]-kB1 (H1), [P24K]-kB1 (H2) and [P24D, V25K]-kB1 (H3) cluster in low moment group. The activity of the cyclotides H1 and H3 against the U937GTB cell line and H. contortus is not known, but they are reported to be inactive against human type A erythrocytes [30].