DMH1, a Small Molecule Inhibitor of BMP Type I Receptors, Suppresses Growth and Invasion of Lung Cancer
Figure 4
DMH1 attenuates xenograft lung tumor growth in mice.
The A549 cells were subcutaneously implanted into the SCID mice followed by intraperitoneal injection of the vehicle (12.5% 2-hydroxypropyl-β-cyclodextrin) or 5 mg/kg DMH1 every other day for 4 weeks. Tumor volumes were measured from the sixth day to four weeks after injection. (B) Representative tumor tissues from mice treated with the vehicle control and DMH1 are compared. (C) Tumor tissues were stained for human specific Ki67 proliferation marker. *: p-value is <0.05.