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Artificial Neural Networks for the Diagnosis of Aggressive Periodontitis Trained by Immunologic Parameters

Figure 3

Bivariate kernel density estimation (KDE) for some selected parameters.

(A) Contour plot for bivariate KDE of longitudinal radiographic bone loss level (sample-1) in relation to age: this topographical-like plot shows a main cluster with 0.2 mm longitudinal bone loss and a small cluster with almost five times greater bone loss. (B) Contour plot for bivariate KDE: By estimating probability density for CD4/CD8 ratio by age (sample-2), we see two clusters although not separated distinctly, at modes of 1.5 and 1.9. (C) Contour plot for bivariate KDE: By estimating probability density for CD4/CD8 ratio (sample-2) by disease severity (% of teeth with bone loss ≥ of 50% of their root length), we reveal two distinct clusters of patients, with modes at x values of 1.5 and 1.9.

Figure 3

doi: https://doi.org/10.1371/journal.pone.0089757.g003