Magnesium Inhibits Wnt/β-Catenin Activity and Reverses the Osteogenic Transformation of Vascular Smooth Muscle Cells
Figure 1
The effect of magnesium on calcification and osteoblast-like transformation in VSMC in vitro.
VSMC were cultured with 3.3 mM P, and increasing concentrations of magnesium (0.8 mM/1.4 mM/2.6 mM); control group with 0.9 mM P+0.8 mM Mg was also included. (A), calcium content of VSMC cultured for 9 days. Relative mRNA expression of Cbfa-1 (B) and osterix (C); a, P<0.001 vs Control; b, P<0.001 vs VSMC with 3.3 mM P+0.8 mM Mg. Bars are the mean±SE of three experiments in quadruplicate.