Activation of Nlrp3 Inflammasomes Enhances Macrophage Lipid-Deposition and Migration: Implication of a Novel Role of Inflammasome in Atherogenesis
Figure 4
Asc gene knockout inhibited ATP-induced caspase-1 activation in BMMs.
(A) Western blot analysis showing the effect of ATP (2.5 mM, 16 h) on active caspase-1 expression and the quantitative analysis (lower blot). (B) Summarized data of FLICA assays quantifying the relative caspase-1 activity compared to control. * P<0.05 vs. untreated Asc+/+ control group; # P<0.05 vs. Asc+/+ ATP group (n = 6).