Activation of Nlrp3 Inflammasomes Enhances Macrophage Lipid-Deposition and Migration: Implication of a Novel Role of Inflammasome in Atherogenesis
Figure 1
ATP, cholesterol crystal or 7-ketocholesterol increased inflammasome formation in Asc+/+ BMMs.
(A) Representative confocal fluorescence images and summarized data depicting the effect of ATP (0–7.5 mM, 16 h) on the colocalization between Nlrp3 and Asc or caspase-1 in Asc+/+ BMMs. (B) Representative confocal fluorescence images and summarized data depicting the effect of cholesterol crystal (0–1 mg/ml, 16 h) on the colocalization between Nlrp3 and Asc or caspase-1 in Asc+/+ BMMs. (C) Representative confocal fluorescence images and summarized data depicting the effect of 7-ketocholesterol (0–20 µg/ml, 16 h) on the colocalization between Nlrp3 and Asc or caspase-1 in Asc+/+ BMMs. * P<0.05 vs. untreated control group (n = 6).