Effects of Reusing Baseline Volumes of Interest by Applying (Non-)Rigid Image Registration on Positron Emission Tomography Response Assessments
Figure 5
Response classifications for early and late response assessments.
Response classifications for early (left part of each subfigure) and late (right part of each subfigure) response assessments based on maximum standardized uptake value (SUVmax; A), SUVmean (B), SUVpeak (C), metabolically active tumour volume (MATV; D), total lesion glycolysis (TLG; E) or area under a cumulative SUV-volume histogram curve (AUC; F). The response values were obtained using A50, local or global rigid image registration, or non-rigid image registration. Abbreviations: PMD, progressive metabolic disease; SMD, stable metabolic disease; PMR, partial metabolic response; IUH, an increase in tracer uptake heterogeneity; SUH, stable tracer uptake heterogeneity; DUH, a decrease in tracer uptake heterogeneity; A50, 3 dimensional (semi-)automatic isocontour method at 50% of the maximum pixel value that corrects for local background.