Effects of Reusing Baseline Volumes of Interest by Applying (Non-)Rigid Image Registration on Positron Emission Tomography Response Assessments
Figure 4
Effects on responses of various quantitative measures obtained using A50 and various registration strategies.
Box plots illustrating the effects of various registration strategies on early (A, C, E, G, I and K) and late (B, D, F, H, J and L) responses derived from maximum standardized uptake value (SUVmax; A, B), SUVmean (C, D), SUVpeak (E, F), metabolically active tumour volume (MATV; G, H), total lesion glycolysis (TLG; I, J) or area under a cumulative SUV-volume histogram curve (AUC; K, L). Responses were calculated as the values of the (early or late) response scans divided by the values of the baseline scan times 100%. The mean is illustrated by a square, outliers by dots, and minimum and maximum values by crosses. Note that one data point for A50 falls outside the scale of subfigure G (447%). Abbreviations: A50, 3 dimensional (semi-)automatic isocontour method at 50% of the maximum pixel value that corrects for local background.