Effects of Reusing Baseline Volumes of Interest by Applying (Non-)Rigid Image Registration on Positron Emission Tomography Response Assessments
Figure 3
Correlation between Dice similarity coefficients and metabolically active tumour volume or tracer uptake heterogenity.
Correlation between Dice similarity coefficients (DSC) obtained using non-rigid PET registration and (A) absolute MATV response values obtained using A50, (B) absolute baseline MATV values obtained using A50, (C) absolute AUC response values obtained using A50, (D) absolute AUC response values obtained using non-rigid PET registration. The two lines represent the trend lines. Note that one data point for late response assessments falls outside the scale of subfigure B (DSC: 0.37, MATV: 500 ml). Abbreviations: MATV, metabolically active tumour volume; AUC, area under a cumulative SUV-volume histogram curve; A50; 3 dimensional (semi-)automatic isocontour method at 50% of the maximum pixel value that corrects for local background.