Computational Study on the Inhibitor Binding Mode and Allosteric Regulation Mechanism in Hepatitis C Virus NS3/4A Protein
Figure 10
Porcupine plots of the eigenvectors for simulation of apo HCV NS3/4A protein (truncated).
The model is shown as a backbone trace. The arrows attached to each backbone atom indicate the direction of the eigenvector and the size of each arrow shows the magnitude of the corresponding eigenvalue. Regions of HCV NS3/4A helicase residues 614–625 and protease residues 103–171 involved in domain movement are highlighted with blue and red, respectively.