Computational Study on the Inhibitor Binding Mode and Allosteric Regulation Mechanism in Hepatitis C Virus NS3/4A Protein
Figure 4
Hydrogen bond network between the C-terminal β-strand of helicase and protease active site in HCV NS3/4A protein (apo).
The protease and helicase domains are shown in cartoon and colored in gray. The six C-terminal residues of the helicase and the protease active site residues are represented by orange and red sticks, respectively. Green dashed lines represent the hydrogen bond.