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Structural and Regulatory Elements of HCV NS5B Polymerase – β-Loop and C-Terminal Tail – Are Required for Activity of Allosteric Thumb Site II Inhibitors

Table 1

Equilibrium dissociation constants (KD) for binding of NNIs to Δ21 and fold-shifts in KD for association to Δ55 and Δ21-Δ8 determined by SPR.

Table 1

doi: https://doi.org/10.1371/journal.pone.0084808.t001