New In Vitro Phenotypic Assay for Epilepsy: Fluorescent Measurement of Synchronized Neuronal Calcium Oscillations
Figure 4
Changes in Calcium oscillations in response to application of classic antiepileptic drugs.
(A-G) Representative recordings of cultures exposed to antiepileptic drugs that work by enhancing GABA receptor activity (A-B), inhibiting sodium channels (C-D) and inhibiting calcium channels (E-G). While other AEDs showed activity in the model, ethosuximide turned from inactive to excitatory at doses higher than 500µM. Time exposed to the compound denoted by blue bar is 6 minutes.