Preconditioning via Angiotensin Type 2 Receptor Activation Improves Therapeutic Efficacy of Bone Marrow Mononuclear Cells for Cardiac Repair
Figure 5
AT2R Stimulation Enhanced Survival of Transplanted BMMNCs in the Region of Ischemic Myocardium in vivo.
Donor BMMNCs derived from males rats were injected into female rats intramyocardially. 3 days after injection, the abundance of sry gene in ischemic (A) and non-ischemic region (B) of heart tissue was determined by real-time PCR. BMMNCs group n=3; and other groups n=4. *P < 0.05 versus BMMNCs group, and #P < 0.05 versus BMMNCs+AngII+Valsartan+PD123319 group.