Egg-Derived Tri-Peptide IRW Exerts Antihypertensive Effects in Spontaneously Hypertensive Rats
Figure 3
IRW treatment restores the nitric oxide contribution to vasodilatation in mesenteric arteries of SHRs.
(A) IRW at the high dose (15mg/Kg BW) but not at the low dose (3mg/Kg BW) significantly increased maximal vasorelaxation in response to MCh. (B, C and D) Addition of L-NAME (100 µM) prior to MCh treatment attenuated vasorelaxation in the high dose (D) but not in the low dose (C) or the untreated (B) groups. Data represented as mean ± SEM from n=6 animals per treatment group. * indicates P<0.05 compared to the untreated group.