Pharmacophore Modeling and Virtual Screening for the Discovery of New type 4 cAMP Phosphodiesterase (PDE4) Inhibitors
Figure 9
Pharmacophore mapping of PD00519 and compound 1 as predicted by molecular docking.
Active site residues are shown in stick form. PD00519 and compound 1 are color-coded: green – PD00519, cyan – compound 1. Pharmacophore features are color-coded: cyan, hydrophobic (HY); orange, ring aromatic (RA); green, hydrogen bond acceptor (HBA).