Pharmacophore Modeling and Virtual Screening for the Discovery of New type 4 cAMP Phosphodiesterase (PDE4) Inhibitors
Figure 8
The positions of PD00519 and compound 1 as predicted by molecular docking.
(A) Molecular overlay of PD00519 and compound 1 shown at the active site of PDE4. (B) The docking positions of PD00519 and compound 1 in the crystal structure of PDE4. PD00519 and compound 1 are color-coded: yellow – PD00519, cyan – compound 1.