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Pharmacophore Modeling and Virtual Screening for the Discovery of New type 4 cAMP Phosphodiesterase (PDE4) Inhibitors

Figure 3

Pharmacophore Mapping.

(A) Mapping of the most active compound 1 on the best pharmacophore model, Hypo1. (B) Mapping of the least active compound 28 on the best pharmacophore model, Hypo1. Pharmacophore features are color-coded: cyan, hydrophobic (HY); orange, ring aromatic (RA); green, hydrogen bond acceptor (HBA).

Figure 3

doi: https://doi.org/10.1371/journal.pone.0082360.g003