Pharmacophore Modeling and Virtual Screening for the Discovery of New type 4 cAMP Phosphodiesterase (PDE4) Inhibitors
Figure 2
The best HypoGen pharmacophore model, Hypo1.
(A) Chemical features present in Hypo 1. (B) 3D spatial relationship and geometric parameters of Hypo1. Pharmacophore features are color-coded (cyan, hydrophobic; orange, ring aromatic; green, hydrogen bond acceptor). Pharmacophore features are color-coded: cyan, hydrophobic (HY); orange, ring aromatic (RA); green, hydrogen bond acceptor (HBA).