X-Ray Crystal Structure of the Ancestral 3-Ketosteroid Receptor–Progesterone–Mifepristone Complex Shows Mifepristone Bound at the Coactivator Binding Interface
Figure 7
Mifepristone and 4-hydroxytamoxifen show similar binding modes to the steroid receptor coactivator binding cleft.
Alignment of the ancSR2–progesterone–mifepristone crystal structure and the ERβ–tamoxifen structure shows both mifepristone and 4-hydroxytamoxifen bound to the coactivator cleft. ancSR2 – slate blue, mifepristone – magenta, ERβ – light green, tamoxifen – orange.