X-Ray Crystal Structure of the Ancestral 3-Ketosteroid Receptor–Progesterone–Mifepristone Complex Shows Mifepristone Bound at the Coactivator Binding Interface
Figure 4
Mifepristone binding site interactions.
ancSR2 is shown in slate blue; mifepristone is shown in magenta (oxygens, red; nitrogens, blue). Residues within 4.2 Å of the ligand are shown. A. Site-one mifepristone interacts with both the monomer in the asymmetric unit as well as residues in a symmetry mate (forest green). B. Site-two mifepristone interacts with residues in the ancSR2 coactivator cleft.