X-Ray Crystal Structure of the Ancestral 3-Ketosteroid Receptor–Progesterone–Mifepristone Complex Shows Mifepristone Bound at the Coactivator Binding Interface
Figure 1
Crystals of the ancSR2–progesterone–mifepristone complex and in vitro activation data.
A. The ancSR2–progesterone–mifepristone ternary complex crystals measured approximately 50 x 20 x 20 microns. B. In luciferase reporter assays, ancSR2 is strongly activated by mifepristone (EC50 = 56 ± 1.2 nM) as well as progesterone (EC50 = 78 ± 1.7 pM).