A Simple Method for Assessing Free Brain/Free Plasma Ratios Using an In Vitro Model of the Blood Brain Barrier
Figure 4
Relationship between in vitro predicted steady-state Cu,br/Cu,pl and in vivo Cu,br/Cu,pl obtained using fu,b from brain slice for 30 drugs and 62 proprietary compounds.
The dashed lines represent a 2-fold over- or underestimation compared with in vivo Cu,br/Cu,pl. Individual values for drugs as well as proprietary compounds are defined in Table 2 and 3.