Mapping the Structural and Dynamical Features of Multiple p53 DNA Binding Domains: Insights into Loop 1 Intrinsic Dynamics
Figure 10
The proposed rescue mutants of L1 for the oncogenic R248Q, whose L3 experiences enhanced flexibility due to the mutation.
In the L114R mutant, R114 forms hydrogen bonds with S116 of L1 and C124. In the G117R mutant, R117 forms a hydrogen bonds with A119. In the T118N mutant, N118 forms a hydrogen bond with R283. In each panel, L1, L2, L3 and DNA are colored in blue, green, red and pink, respectively.