Mapping the Structural and Dynamical Features of Multiple p53 DNA Binding Domains: Insights into Loop 1 Intrinsic Dynamics
Figure 6
Cross-correlated motions of p53 DNA binding domain.
(Upper panel) The anti-correlated motions (A-C) that are present in extended L1 but absent in recessed L1 conformers are colored in pink on the p53 DBD structures. The orientations of p53 DBD structures are the same as in Figure 1C.
(Lower panel) The map of cross-correlated motions of extended L1 conformers (in upper triangle) and recessed L1 conformers (in lower triangle) shows different patterns between particular regions. For clarity, only correlated motions with absolute normalized values of at least 0.25 are shown. Motion occurring along the same direction is represented by positive correlation (cyan), whereas motion occurring along opposite directions is represented by negative (anti-) correlation (pink).