N-Cadherin Relocalizes from the Periphery to the Center of the Synapse after Transient Synaptic Stimulation in Hippocampal Neurons
Figure 5
N-cadherin relocalizes to the center of the synapse after transient synaptic stimulation.
(A) In unstimulated neurons, N-cadherin is present at synapses in a variety of distributions. It is primarily found as puncta near the edges of the active zone, but can also be present as a more uniform distribution along the synaptic cleft. (B) During KCl depolarization, there is less N-cadherin in the central region along the active zone, and more N-cadherin at periphery of the active zone. (C) After transient synaptic stimulation with KCl, N-cadherin relocalizes to form a broader central distribution along the active zone. This change in N-cadherin localization may have consequences for the increase in synaptic strength and stability following synaptic activity.