Sex-Specific Effects of High Fat Diet on Indices of Metabolic Syndrome in 3xTg-AD Mice: Implications for Alzheimer's Disease
Figure 5
High fat diet increases Aβ accumulation in the hippocampus of male and female 3xTg-AD mice.
A, Hippocampus CA1 Aβ immunoreactivity load values. B–E, Representative photomicrographs show Aβ immunoreactivity in the hippocampus CA1 regions in standard diet fed male (B) and female (C) 3xTg-AD mice, and high fat fed male (D) and female (E) 3xTg-AD mice. F, Subiculum Aβ immunoreactivity load values. G–J, Representative photomicrographs show Aβ immunoreactivity in the subiculum regions in standard diet fed male (G) and female (H) 3xTg-AD mice, and high fat fed male (I) and female (J) 3xTg-AD mice. Data presented as means ± SEM. *p<0.05 compared to all other groups. *p<0.001 relative to matched sex with standard diet.