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Methylcobalamin Facilitates Collateral Sprouting of Donor Axons and Innervation of Recipient Muscle in End-to-Side Neurorrhaphy in Rats

Figure 5

Cross sections of the distal segments of the ESN repaired nerves.

Representative micrographs of animals 1 (upper row), 3 (middle row) and 6 months (lower row) following ESN were illustrated. Each micrograph was taken from a toluidine blue-stained, semithin cross section of the recipient nerve 1 mm distal to the neurorrhaphy site. The nerve was embedded in plastic. Micrographs from PBS, MeB12 and MeB12+PTN-treated ESN animals are illustrated. Scale bar = 25 µm for all.

Figure 5

doi: https://doi.org/10.1371/journal.pone.0076302.g005