High-Throughput Screening (HTS) and Hit Validation to Identify Small Molecule Inhibitors with Activity against NS3/4A proteases from Multiple Hepatitis C Virus Genotypes
Figure 7
Preliminary Structure and Activity Relationship (SAR) of Compound 12.
Out of 25 structurally similar Life Chemicals compounds and 28 additional compounds from a scaffold search based on 12, % inhibition and IC50 values of 13 compounds are shown for comparison. IC50 values were determined from two to four independent assays. The percent inhibitions of each compound are shown in parenthesis in cases of IC50 value above 100 µM at 50 µM compound concentration.