Biosynthesis of Sandalwood Oil: Santalum album CYP76F Cytochromes P450 Produce Santalols and Bergamotol
Figure 1
Schematic biosynthetic pathway for santalols and bergamotol in sandalwood.
Compounds identified with numbers are: α-santalene (1), α-exo-bergamotene (2), epi-β-santalene (3), β-santalene (4), (Z)-α-santalol (5), (E)-α-santalol (7), (Z)-α-exo-bergamotol (6), (E)-α-exo-bergamotol (8), (Z)-epi-β-santalol (9), (E)-epi-β-santalol (11), (Z)-β-santalol (10), (E)-β-santalol (12). Numbers match the numbers in Table 1. DMADP, dimethylallyl diphosphate; IPP, isopentenyl diphosphate; FPP, farnesyl diphosphate; FPPS, farnesyl diphosphate synthase; SaSSy, S. album santalene synthase.