Effects of Elaidic Acid on Lipid Metabolism in HepG2 Cells, Investigated by an Integrated Approach of Lipidomics, Transcriptomics and Proteomics
Figure 3
Search space comparison of genes and proteins for the comparison of EvsO differentially expressed genes/proteins in SILAC and GEMA.
Panel A. Comparison of search spaces containing all genes/proteins quantified in SILAC and GEMA analyses. Panel B. Numbers of differentially expressed genes/proteins in the EvsO comparison according to method (SILAC fold change >1.3, p-value <0.01; GEMA fold change >1.5, BH-p-value <0.01). Red numbers indicate up-regulations while green indicates down-regulations. The brown number indicates genes/proteins found down-regulated in SILAC while up-regulated in GEMA. In both GEMA and SILAC, 7% of the genes/proteins in the respective search spaces were found to be regulated in the EvsO comparison.