Solvent Dependency of the UV-Vis Spectrum of Indenoisoquinolines: Role of Keto-Oxygens as Polarity Interaction Probes
Figure 1
Compounds under investigation.
A) Schematic representation of AI-III-52 (left) and MJ-238 (right) IQN derivatives for which the X-ray structures of the Top1-DNA-drug complex are available (PDB-ID 1TL8 and 1SC7 for AI-III-52 and MJ-238 respectively). The compounds have the same relative orientation observed in the X-ray structure B) Chemical structure of the investigated indenoisoquinolines.