Geometry-Driven Cell Organization Determines Tissue Growths in Scaffold Pores: Consequences for Fibronectin Organization
Figure 7
Schematic representation of pore filling as a function of time.
Cells are represented by tensioned chords in green and fibronectin is in red. Initially cells are spreading on the pore wall and fibronectin is being produced but not visible as a connected network yet by the cells (top). The pore is subsequently filled by cells with time according to the model and produce fibronectin fibers being unfolded due to cell forces (middle). Finally the pore closes completely and at the same time fibronectin is further compacted towards the center (bottom).